New therapies for recurrent glioblastomas
نویسندگان
چکیده
منابع مشابه
New therapies for recurrent glioblastomas
Glioblastomas are the most common and deadliest form of malignant primary brain tumor. Until recently, therapies for tumors that recur after standard treatment have been largely ineffective. Recent phase II studies with the humanized monoclonal antibody against vascular endothelial growth factor bevacizumab suggest that this agent is active in recurrent glioblastomas, producing response rates o...
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INTRODUCTION Glioblastoma (GBM), the most common primary malignant brain tumor in adults, lacks effective long-term treatment. The tumor is dependent on neovascularization for survival, making angiogenesis an attractive target for therapeutic intervention. The exact mechanism underlying the effects of antiangiogenic agents on GBM remains debatable, although it likely involves vascular endotheli...
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In patients with glioblastoma, antiangiogenic therapy with bevacizumab (BEV) has been shown to improve progression-free survival (PFS), but not overall survival (OS). Especially in patients with an unusual infiltrative phenotype as seen in multifocal glioblastoma, the use of BEV therapy is still more controversial. Therefore, we prepared a retrospective case series with 16 patients suffering fr...
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According to the National Brain Tumor Society, over 120 different types of human brain tumors have been described, the most common of which are gliomas arising from glial (supportive) cells. Approximately two-thirds of brain tumors are benign, but about one third aremalignant. Themost common adult-onset primary (i.e., arising from the brain itself) malignant brain tumor is glioblastoma multifor...
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ژورنال
عنوان ژورنال: F1000 Medicine Reports
سال: 2009
ISSN: 1757-5931
DOI: 10.3410/m1-94